Bacterial pathogens and death during the 1918 influenza pandemic

YW Chien, KP Klugman… - New England Journal of …, 2009 - Mass Medical Soc
YW Chien, KP Klugman, DM Morens
New England Journal of Medicine, 2009Mass Medical Soc
To the Editor: A review of recut lung-tissue specimens and published autopsy series from the
1918 influenza pandemic suggests that secondary bacterial pneumonia1 was an important
cause of death, consistent with our preliminary analysis of antemortem blood cultures and
the time to death of the patients. 2 We review here studies that reported more than 10 sterile-
site antemortem cultures from adults with pneumonia and those without pneumonia in an
extensive archive of articles about the 1918 pandemic in any language (www3. niaid. nih …
To the Editor: A review of recut lung-tissue specimens and published autopsy series from the 1918 influenza pandemic suggests that secondary bacterial pneumonia1 was an important cause of death, consistent with our preliminary analysis of antemortem blood cultures and the time to death of the patients.2 We review here studies that reported more than 10 sterile-site antemortem cultures from adults with pneumonia and those without pneumonia in an extensive archive of articles about the 1918 pandemic in any language (www3.niaid.nih.gov/topics/Flu/1918/bibliography.htm). Bacteria were recovered in only a few blood cultures for patients who had influenza but not pneumonia (mean among all . . .
The New England Journal Of Medicine